Mtor

Houghton, Peter J./Polunovsky, Vitaly A. mTOR Pathway and mTOR Inhibitors in Cancer Therapy Cancer Drug Discovery and Development, SPRINGER, BERLIN, August 2010 ISBN: 1603272704
mTOR Pathway and mTOR Inhibitors in Cancer Therapy provides an up-to-date survey of the rapidly advancing field of cancer therapy. Our understanding of the mechanisms involved in cancer genesis and progression underwent unprecedented expansion during the last decade, opening a new era of cancer treatment targeted therapy. The surge in this area results in no small part from studies conducted jointly by basic health scientists and clinical investigators. It is our hope that this book will help foster even further collaboration between investigators in these two disciplines. In this work, experts in TOR signaling have contributed in two thematic areas: mTOR Signaling and Cancer Therapy (chapters 1 - 8) and Therapeutic Targeting Downstream of mTOR (chapter 9 13). All chapters of mTOR Pathway and mTOR Inhibitors in Cancer Therapy are completely new or have been extensively updated by their authors; and we are indebted to all authors who have exemplified the links between these 2 thematic areas.

NEUBUCH! 2010. XII, 304 S. 14 SW-Abb., 12 Farbabb., 3 Farbtabellen. 235 mm 244 mm x 167 mm x 27 mm Approx. 250 p; Cancer Drug Discovery and Development

[SW: Krebs (Krankheit) / Therapie (diverse)]

Details

Weichhart, Thomas: mTOR Methods and Protocols, SPRINGER, BERLIN, Februar 2012 ISBN: 1617794295
Since its discovery, the mammalian target of rapamycin (mTOR) has been shown to regulate many critical molecular processes in eukaryotes such as metabolism, growth, survival, aging, synaptic plasticity, memory, and immunity. In mTOR: Methods and Protocols expert researchers in the field detail many of the methods which are now commonly used to study mTOR. These include methods and techniques used for the study of the mTOR pathway and potential therapeutic applications of mTOR inhibitors such as, immunosuppressive and anticancer agents. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, mTOR: Methods and Protocols seeks to aid scientists in the further study of this crucially important molecule ranging from the analysis of signal transduction events within a cell to the assessment of complex human diseases such as metabolic disorders or cancer.

NEUBUCH! 2012. 435 S. 71 SW-Abb., 23 Farbabb., 11 Tabellen 263 mm x 185 mm x 33 mm 71 schwarz-weiße und 23 farbige Abbildungen, 11 schwarz-weiße Tabellen; Methods in Molecular Biology .821

[SW: Biologie / Zellbiologie, Zellbiologie, Zelle (biologisch) / Zellbiologie]

Details

Borg, Holly M. Brown-/Brown-Borg, Holly M./Lorenzini, Antonello/Sell, Christian: Life Span Extension Single Cell Organisms to Man, SPRINGER, BERLIN; HUMANA PRESS, 099 ISBN: 1603275061
In recent years, remarkable discoveries have been made concerning the underlying mechanisms of aging. In Life-Span Extension: Single-Cell Organisms to Man, the editors bring together a range of illuminating perspectives from researchers investigating the aging process in a variety of species. This novel work addresses the aging process in species ranging from yeast to man and, among other subjects, features detailed discussions of the naked mole-rat, an exceptionally long-lived rodent; the relationship between dietary factors/food restriction and aging; and an evolutionary view of the human aging process.Single mutations that extend life span have been identified in yeast, worms, flies, and mice, whereas studies in humans have identified potentially important markers for successful aging. At the same time, it has been discovered that the genes and pathways identified in these studies involve a surprisingly small set of conserved functions, most of which have been the focus of aging research for some time. For example, the mTOR pathway, a regulator of translation and protein synthesis, has been identified as a common longevity pathway in yeast and Caenorhabditis elegans. In mammals, this pathway intersects with neuroendocrine pathways and with the insulin/insulin-like growth factor pathways, which have been identified as major modulators of life span and aging in both invertebrates and mice.Novel, emerging technologies and the increasingly wide variety of systems that are now used to study aging and the mechanisms of aging provide enormous opportunities for the identification of common pathways that modulate longevity. It is these common pathways that are the focus of this important volume.

NEUBUCH! 2009. 350 p. 260 mm 235 mm x 155 mm x 18 mm 20 schwarz-weiße und 5 farbige Abbildungen, 1 schwarz-weiße Fotos, 5 farbige Zeichn., 5 schwarz-weiße Tabellen

[SW: Altern]

Details

Land, Walter Gottlieb: Immunsuppressive Therapie, Band 3: mTor-hemmende Medikamente, IMPDH-hemmende Medikamente, DHODH-hemmende Medikamente, monoklonole Anti-T-Zell-(Anti-CD25-)Antikörper (Sonderausgabe in 4 Bänden) Stuttgart - New York, Thieme, 2004. -

60 Abb., 16 Tab., 139 S. kartoniert

Details